Abstract |
The safe and effective drug delivery system is important for cancer therapy. Here in, we first constructed a delivery system Cabazitaxel(Cab)@MPN/CS between metal- polyphenol (MPN) and chitosan (CS) to deliver Cab for melanoma therapy. The preparation process is simple, green, and controllable. After introducing CS coating, the drug loading was improved from 7.56 % to 9.28 %. Cab@MPN/CS NPs released Cab continuously under acid tumor microenvironment. The zeta potential of Cab@MPN/CS NPs could be controlled by changing the ratio of Cab@MPN and CS solutions. The positively charged Cab@MPN/CS accelerate B16F10 cell internalization. After internalized, Cab@MPN/CS NPs could escape from lysosomes via the proton sponge effect. The permeability of CS promotes the penetration of Cab@MPN/CS to the deeper B16F10 tumor spheroids. In vivo results showed that Cab@MPN/CS NPs have a longer retention time in tumor tissues and significantly inhibit tumor growth by up-regulating TUNEL expression and down-regulating KI67 and CD31 expression. Thus, this delivery system provides a promising strategy for the tumor therapy in clinic.
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Authors | Min Mu, Xiaoyan Liang, Di Chuan, Shasha Zhao, Wei Yu, Rangrang Fan, Aiping Tong, Na Zhao, Bo Han, Gang Guo |
Journal | Carbohydrate polymers
(Carbohydr Polym)
Vol. 264
Pg. 118000
(Jul 15 2021)
ISSN: 1879-1344 [Electronic] England |
PMID | 33910734
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Drug Carriers
- Ki-67 Antigen
- Platelet Endothelial Cell Adhesion Molecule-1
- Polyphenols
- Taxoids
- cabazitaxel
- Chitosan
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Topics |
- Animals
- Antineoplastic Agents
(chemistry, pharmacology)
- Apoptosis
(drug effects)
- Cell Line, Tumor
- Chitosan
(chemistry)
- Drug Carriers
(chemistry)
- Drug Delivery Systems
(methods)
- Drug Liberation
- Hydrogen-Ion Concentration
- Ki-67 Antigen
(metabolism)
- Melanoma
(drug therapy, metabolism)
- Metal Nanoparticles
(chemistry)
- Mice
- Particle Size
- Platelet Endothelial Cell Adhesion Molecule-1
(metabolism)
- Polyphenols
(chemistry)
- Taxoids
(chemistry, pharmacology)
- Tumor Microenvironment
(drug effects)
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