HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Chitosan coated pH-responsive metal-polyphenol delivery platform for melanoma chemotherapy.

Abstract
The safe and effective drug delivery system is important for cancer therapy. Here in, we first constructed a delivery system Cabazitaxel(Cab)@MPN/CS between metal-polyphenol (MPN) and chitosan (CS) to deliver Cab for melanoma therapy. The preparation process is simple, green, and controllable. After introducing CS coating, the drug loading was improved from 7.56 % to 9.28 %. Cab@MPN/CS NPs released Cab continuously under acid tumor microenvironment. The zeta potential of Cab@MPN/CS NPs could be controlled by changing the ratio of Cab@MPN and CS solutions. The positively charged Cab@MPN/CS accelerate B16F10 cell internalization. After internalized, Cab@MPN/CS NPs could escape from lysosomes via the proton sponge effect. The permeability of CS promotes the penetration of Cab@MPN/CS to the deeper B16F10 tumor spheroids. In vivo results showed that Cab@MPN/CS NPs have a longer retention time in tumor tissues and significantly inhibit tumor growth by up-regulating TUNEL expression and down-regulating KI67 and CD31 expression. Thus, this delivery system provides a promising strategy for the tumor therapy in clinic.
AuthorsMin Mu, Xiaoyan Liang, Di Chuan, Shasha Zhao, Wei Yu, Rangrang Fan, Aiping Tong, Na Zhao, Bo Han, Gang Guo
JournalCarbohydrate polymers (Carbohydr Polym) Vol. 264 Pg. 118000 (Jul 15 2021) ISSN: 1879-1344 [Electronic] England
PMID33910734 (Publication Type: Journal Article)
CopyrightCopyright © 2021 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Drug Carriers
  • Ki-67 Antigen
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Polyphenols
  • Taxoids
  • cabazitaxel
  • Chitosan
Topics
  • Animals
  • Antineoplastic Agents (chemistry, pharmacology)
  • Apoptosis (drug effects)
  • Cell Line, Tumor
  • Chitosan (chemistry)
  • Drug Carriers (chemistry)
  • Drug Delivery Systems (methods)
  • Drug Liberation
  • Hydrogen-Ion Concentration
  • Ki-67 Antigen (metabolism)
  • Melanoma (drug therapy, metabolism)
  • Metal Nanoparticles (chemistry)
  • Mice
  • Particle Size
  • Platelet Endothelial Cell Adhesion Molecule-1 (metabolism)
  • Polyphenols (chemistry)
  • Taxoids (chemistry, pharmacology)
  • Tumor Microenvironment (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: