Abstract | Aim: Methods: In a randomized controlled multicentre study, 72 participants with T2D and moderate to severe OSA (78% male, age 62 ± 7, AHI 35 ± 15) were recruited from outpatient clinics in three Danish hospitals and were randomized to CPAP intervention or control. The main outcome was glycaemic control assessed by 6 days CGM at baseline and after 12-week therapy, as well as by HbA1c and fasting blood glucose. Results: No significant changes were found in average glucose levels, time in glucose range, time with hypoglycaemia, time with hyperglycaemia or coefficient of variability. HbA1c decreased 0.7 mmol/mol (0.07%; P = .8) in the CPAP group and increased 0.8 mmol/mol (0.08%; P = .6) in the control group (intergroup difference, P = .6). Fasting blood glucose increased by 0.2 mmol/L (P = .02) in the CPAP group and by 0.4 mmol/L (P = .01) in the control group (intergroup difference, P = .7). In a prespecified subgroup analysis comparing participants with high adherence (minimum usage of four hours/night for 70% of all nights) to CPAP to the control group, no significant changes were observed either, although these participants had a tendency towards better glycaemic indices. Conclusions: CPAP treatment for 12 weeks does not significantly change glycaemic control in patients with type 2 diabetes and OSA.
|
Authors | Anne Margareta Banghøj, Christoffer Krogager, Peter Lommer Kristensen, Klavs Würgler Hansen, Esben Laugesen, Jesper Fleischer, Simon Lebech Cichosz, Per Løgstrup Poulsen, Martin Glymer Kirkegaard, Birger Thorsteinsson, Lise Tarnow |
Journal | Endocrinology, diabetes & metabolism
(Endocrinol Diabetes Metab)
Vol. 4
Issue 2
Pg. e00148
(04 2021)
ISSN: 2398-9238 [Electronic] England |
PMID | 33855195
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | © 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. |
Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- hemoglobin A1c protein, human
|
Topics |
- Aged
- Blood Glucose
- Blood Glucose Self-Monitoring
- Continuous Positive Airway Pressure
- Diabetes Mellitus, Type 2
(blood, complications)
- Female
- Glycated Hemoglobin
- Glycemic Control
- Humans
- Male
- Middle Aged
- Negative Results
- Severity of Illness Index
- Sleep Apnea, Obstructive
(blood, complications, therapy)
- Time Factors
|