Abstract | OBJECTIVE: OBJECTIVE: Female SCID mice were randomly divided into blank control group and high-, moderate-, and low-dose cetuximab groups. The mice in control group received intraperitoneal injection of saline, and those in the 3 cetuximab groups were injected with 80, 40, and 20 mg/kg cetuximab (3 times a week for 4 weeks), respectively. The general skin appearance and skin pathologies of the mice were observed. Female BN rats were randomly divided into blank group, ovalbumin group, gefitinib group and erlotinib group, and in the latter 3 groups, the rats were given ovalbumin (1 mg), gefitinib (37.5 mg/kg), and erlotinib (23.5 mg/kg) by lavage once daily for 45 days, respectively. Skin pathologies of the rats were observed, and serum levels of TNF-α, IL-6 and other inflammatory factors were detected using ELISA. OBJECTIVE:
Intraperitoneal injection of cetuximab did not induce typical skin rashes, scabs or obvious skin inflammation in the mice. In female BN rats, lavage of gefitinib caused obvious skin rashes, scabs and exudation, and obvious inflammatory cell infiltration, keratinosis, spinous layer release and epidermal thickening were observed in the skin. No obvious skin inflammation were observed in the rats in the control, ovalbumin or erlotinib groups. While IgE (P=0.061) and TNF-α concentrations (P=0.057) did not differ significantly among the groups, serum levels of IL-6 was significantly higher in gefitinib group than in the blank control group (P=0.016) but similar between erlotinib group and the blank group (P=0.910). OBJECTIVE:
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Authors | X Zhang, C Xue, J Li, J Zhang, K Tan, X Jiang, H Zheng, H Dong, Y Yu, Z Hu, H Cui |
Journal | Nan fang yi ke da xue xue bao = Journal of Southern Medical University
(Nan Fang Yi Ke Da Xue Xue Bao)
Vol. 41
Issue 3
Pg. 352-357
(Mar 25 2021)
ISSN: 1673-4254 [Print] China |
PMID | 33849825
(Publication Type: Journal Article)
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Chemical References |
- Quinazolines
- Erlotinib Hydrochloride
- ErbB Receptors
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Topics |
- Animals
- ErbB Receptors
- Erlotinib Hydrochloride
(toxicity)
- Female
- Lung Neoplasms
- Mice
- Mice, SCID
- Models, Animal
- Quinazolines
(toxicity)
- Rats
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