Acute Cholecystitis Following Allogeneic Hematopoietic Stem Cell Transplantation: Clinical Features, Outcomes, Risk Factors, and Prediction Model.

Abstract

Acute cholecystitis (AC) is a potentially fatal complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT); however, only limited information is available on its clinical features, outcomes, and risk management strategies. This retrospective, nested, case-control study included 6701 patients undergoing allo-HSCT at our center from January 2004 to June 2019. In total, 72 patients (1.1%) were diagnosed with AC; among these, acute acalculous cholecystitis had a slightly higher prevalence (42 patients, 58.3%). Patients with moderate and severe AC exhibited remarkably worse overall survival (P = .001) and non-relapse mortality (P = .011) than others. Survival of haploidentical HSCT recipients with AC was comparable to that for patients with human leukocyte antigen (HLA)-identical donors. Age ≥ 18 years, antecedent stage II to IV acute graft-versus-host disease, and total parenteral nutrition were identified as potential risk factors for AC following allo-HSCT, while haploidentical transplantations were not more susceptible to AC than HLA-identical HSCT. Based on these criteria, a risk score model was developed and validated to estimate the probability of AC following allo-HSCT. The model separates all patients into low-, intermediate-, and high-risk groups and thereby provides a basis for early detection of this complication in the management of allo-HSCT.

• Authors: Zhuangyi Zhang, Yun He, Xiao-Lu Zhu, Xiao Liu, Hai-Xia Fu, Feng-Rong Wang, Xiao-Dong Mo, Yu Wang, Yuan-Yuan Zhang, Wei Han, Yao Chen, Chen-Hua Yan, Jing-Zhi Wang, Yu-Hong Chen, Ying-Jun Chang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, Xiao-Hui Zhang
• Journal: Transplantation and cellular therapy (Transplant Cell Ther) Vol. 27 Issue 3 Pg. 253.e1-253.e9 (03 2021) ISSN: 2666-6367 [Electronic] United States
• PMID: 33781524 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Case-Control Studies
• Cholecystitis, Acute
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Retrospective Studies
• Risk Factors