Case Report: Rapidly Progressive Interstitial Lung Disease in A Pregnant Patient With Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Positive Dermatomyositis.

Abstract

Dermatomyositis occurs extremely rarely during pregnancy. A number of studies in the published literature have documented how the outcome of pregnancy is poor for both mother and fetus. The present case study reports on a patient who was diagnosed with clinically amyopathic dermatomyositis complicated by interstitial lung disease during pregnancy, and was successfully treated with a combined immunosuppressant regimen. To the best of the authors' knowledge, this is the first case study detailing how a pregnant woman with clinically amyopathic dermatomyositis with positive anti-melanoma differentiation-associated gene 5 antibody achieved complete remission after early intervention of combined immunosuppressive therapy without residual pulmonary interstitial changes.

• Authors: Cuihong Chen, Yulan Chen, Qin Huang, Qiu Hu, Xiaoping Hong
• Journal: Frontiers in immunology (Front Immunol) Vol. 12 Pg. 625495 ( 2021) ISSN: 1664-3224 [Electronic] Switzerland
• PMID: 33717138 (Publication Type: Case Reports, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Chen, Chen, Huang, Hu and Hong.

Chemical References

• Antibodies, Monoclonal
• IFIH1 protein, human
• Interferon-Induced Helicase, IFIH1

Topics

• Adult
• Antibodies, Monoclonal (metabolism)
• Dermatomyositis (diagnosis, drug therapy)
• Drug Therapy, Combination
• Drug-Related Side Effects and Adverse Reactions (diagnosis, drug therapy)
• Female
• Humans
• Immunosuppression Therapy
• Interferon-Induced Helicase, IFIH1 (immunology)
• Lung Diseases, Interstitial (diagnosis, drug therapy)
• Paraneoplastic Syndromes (diagnosis, drug therapy)
• Pregnancy
• Pregnancy Complications (diagnosis, drug therapy)
• Remission Induction
• Respiratory Insufficiency