Abstract | PURPOSE: PATIENTS AND METHODS: Twenty-four patients with COPD ( GOLD I, n = 7; GOLD II, n = 8; GOLD III+IV, n = 9) and 14 healthy controls (7 normal pulmonary function; 7 small-airway disease (SAD)) were enrolled in the study as five groups, GOLD I, GOLD II, GOLD III+IV, normal and SAD. All subjects underwent HRCT and spirometry. With ISP 9.0, whole emphysema index (EI) and the airway parameters, including wall area (WA), lumen area (LA), airway area (AA) of the 3rd, 5th and 9th generations of bronchi, were measured successively. The ratio of LA/AA and WA/AA in the 3rd, 5th and 9th generations of bronchi were calculated and compared among groups. RESULTS: For the five groups, EI was increased only in GOLD III+IV group (P < 0.05), while the ratio of LA/AA (9-LA/AA) and WA/AA (9-WA/AA) in 9th generation of bronchi have significantly changed since SAD group (P < 0.05). There were significant correlation between FEV1generations of bronchi (r3 = 0.429, r5 = 0.583, r9 = 0.592, respectively, P < 0.05); FEV1% and WA/AA (r3 = -0.428, r5 = -0.532, r9 = -0.570, respectively, P < 0.05); as well as MMEF% and LA/AA (r3 = 0.421, r5 = 0.566, r9 = 0.610, respectively, P < 0.05); MMEF% and WA/AA (r3 = -0.421, r5 = -0.529, r9 = -0.593, respectively, P < 0.05). CONCLUSION:
|
Authors | Shuyi Qin, Xinjuan Yu, Qianli Ma, Li Lin, Qinghai Li, Hong Liu, Lei Zhang, Shuguang Leng, Wei Han |
Journal | International journal of chronic obstructive pulmonary disease
(Int J Chron Obstruct Pulmon Dis)
2021
Vol. 16
Pg. 535-544
ISSN: 1178-2005 [Electronic] New Zealand |
PMID | 33688178
(Publication Type: Journal Article)
|
Copyright | © 2021 Qin et al. |
Topics |
- Airway Remodeling
- Humans
- Pulmonary Disease, Chronic Obstructive
(diagnostic imaging)
- Pulmonary Emphysema
(diagnostic imaging)
- Respiratory Function Tests
- Tomography, X-Ray Computed
|