The diagnostic value of plasma exosomal hsa_circ_0070396 for hepatocellular carcinoma.

Abstract

Aim: We aimed to identify novel exosomal circular RNAs for hepatocellular carcinoma (HCC) diagnosis. Materials & methods: Exosomes were extracted and characterized. The expression level of exosomal circRNAs were verified via quantitative real-time PCR. The diagnostic value of candidate circRNAs was evaluated according to the receiver operating characteristic curve analysis. Results: The exosomal circ_0070396 significantly elevated in HCC patients than other control groups and it performed better in distinguishing HCC patients from healthy donors than that of α-fetoprotein. Combination of two above markers exerted greater diagnostic performance. Exosomal circ_0070396 could discriminate HCC individuals from patients with chronic hepatitis B and liver cirrhosis. Intriguingly, exosomal circ_0070396 was positively correlated with HCC progression. Conclusion: Exosomal circ_0070396 may be a potential biomarker for HCC detection and management.

• Authors: Lihua Lyu, Wenjing Yang, Jiayi Yao, Hao Wang, Jie Zhu, Anli Jin, Te Liu, Beili Wang, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo
• Journal: Biomarkers in medicine (Biomark Med) Vol. 15 Issue 5 Pg. 359-371 (04 2021) ISSN: 1752-0371 [Electronic] England
• PMID: 33666515 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• RNA, Circular

Topics

• Biomarkers, Tumor (blood, genetics)
• Carcinoma, Hepatocellular (blood, diagnosis, genetics)
• Case-Control Studies
• Exosomes (genetics)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Liver Neoplasms (blood, diagnosis, genetics)
• Male
• Middle Aged
• RNA, Circular (blood, genetics)
• ROC Curve