Colon cancer is one of the fatal
cancers in the world that metastatic potential and resistance to
chemotherapy drugs are outstanding causes of
cancer-induced mortality [1], [2], [3], [4]. We have investigated in vitro and in vivo anti-
cancer effect of
itraconazole and
paclitaxel alone and their anti-
cancer synergistic effect through MTT assay in
YM-1 and HT-29 cell lines and in HT-29
tumor-bearing nude mice. Histopathological experiment was done for further assessment. Also, we evaluated the inhibitory effect of
itraconazole on P-gp using specific in vivo biodistribution through 99mTc-MIBI uptake. 99mTc-MIBI, a myocardial perfusion imaging agent, is a useful radiotracer in diagnosis of some
tumors and the liver and
tumor accumulation of 99mTc-MIBI is changed by P-gp regulators [5], [6], [7], [8]. The data presented in this article are related to the research paper entitled "
Itraconazole synergistically increases
therapeutic effect of
paclitaxel and 99mTc-MIBI accumulation, as a probe of P-gp activity, in HT-29
tumor-bearing nude mice". We hope our preliminary data to be helpful to design the
chemotherapy regimen schedule with
Itraconazole and
Paclitaxel.