Abstract | OBJECTIVE: METHODS: A total of 52 healthy controls and 508 RMD patients were included. We collected 3714 clinical and laboratory records from June 2011 to August 2019, and the longest follow-up period was eleven years. The associations between prealbumin and CRP, the globulin gap, the albumin-to- globulin ratio, and IgG were evaluated. RESULTS:
Prealbumin had a high correlation coefficient (r=-0.497, P<0.001), consistent changes over time with CRP, and a high area under the curve [AUC=0.777 (95% CI 0.76-0.795)] for CRP. The statistical relationship between the prealbumin and CRP was not affected by sex, ethnicity or age. Among RMDs, prealbumin showed the strongest correlation with CRP in Takayasu arteritis (r=0.607, P<0.001). In addition, a moderate relationship was observed between prealbumin and IgG, the globulin gap and the albumin-to- globulin ratio. CONCLUSION:
Prealbumin is closely related to CRP in Chinese patients with five chronic inflammatory RMDs, which may be due to the influence of chronic inflammation during the course of disease.
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Authors | Linlin Cheng, Liubing Li, Chenxi Liu, Songxin Yan, Haizhen Chen, Hua Chen, Fengchun Zhang, Yongzhe Li |
Journal | Annals of clinical and laboratory science
(Ann Clin Lab Sci)
Vol. 51
Issue 1
Pg. 82-89
(Jan 2021)
ISSN: 1550-8080 [Electronic] United States |
PMID | 33653784
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 by the Association of Clinical Scientists, Inc. |
Chemical References |
- Biomarkers
- Prealbumin
- C-Reactive Protein
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Topics |
- Adult
- Biomarkers
(blood)
- C-Reactive Protein
(analysis, metabolism)
- Case-Control Studies
- China
- Female
- Humans
- Inflammation
(blood)
- Male
- Middle Aged
- Musculoskeletal Diseases
(metabolism, physiopathology)
- Prealbumin
(analysis, metabolism)
- ROC Curve
- Rheumatic Diseases
(metabolism, physiopathology)
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