Abstract | BACKGROUND: CASE PRESENTATION: A 4-year-old Filipino girl had increased frequency of daytime urinary incontinence and foul-smelling urine since the age of 3. Clinical examination revealed constipation, and urinalysis revealed bacteriuria. Voiding cystourethrography revealed an enlarged and trabeculated bladder without vesicoureteral reflux. On the urodynamic study (UDS), she was found to have detrusor overactivity (DO) and low bladder compliance. She could not void and was diagnosed with overflow incontinence. Clean intermittent catheterization (CIC) and orally administered propiverine (0.8 mg/kg/day) were initiated, and urinary incontinence was resolved. She underwent a UDS annually; the UDS at 6 years of age still revealed DO and low bladder compliance in spite of receiving propiverine. The treatment was switched from propiverine to vibegron (1.4 mg/kg/day). On the UDS after a 5-week treatment schedule of vibegron, the DO disappeared and the bladder compliance improved. CIC and orally administered vibegron have been continued for 7 months so far, and she has had no urinary tract infection with no drug-related adverse events. CONCLUSIONS:
|
Authors | Taiki Kato, Kentaro Mizuno, Hidenori Nishio, Takahiro Yasui, Yutaro Hayashi |
Journal | Journal of medical case reports
(J Med Case Rep)
Vol. 15
Issue 1
Pg. 86
(Feb 18 2021)
ISSN: 1752-1947 [Electronic] England |
PMID | 33602290
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Cholinergic Antagonists
- N-(4-((5-(hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4-oxo-4,6,7,8-tetrahydropyrrolo(1,2-a)pyrimidine-6-carboxamide
- Pyrimidinones
- Pyrrolidines
|
Topics |
- Adult
- Child
- Child, Preschool
- Cholinergic Antagonists
- Female
- Humans
- Pyrimidinones
- Pyrrolidines
- Treatment Outcome
- Urinary Bladder, Overactive
(drug therapy)
- Urodynamics
|