Abstract | BACKGROUND: METHODS: This was a nationwide population cohort study involving 5395 patients with acute leukemia who underwent allo-HCT between 2003 and 2015. Patient data were collected from the Korean National Health Insurance Service database. We investigated the cumulative incidence rates (CIRs) of early TRM at 50 and 100 days. RESULTS: The CIRs of early TRM at 50 and 100 days were 2.9 and 8.3%, respectively. There was no decrease in the CIRs of early TRM over time. The early mortality was significantly higher in patients with more than 9 months between the diagnosis and transplantation (CIRs of TRM at 50, 100 days; 6.0, 13.2%), previous transplantations (CIRs of TRM at 50, 100 days; 9.4, 17.2%), and cord blood transplantation (CIRs of TRM at 50, 100 days; 6.1, 8.3%). The early TRM was significantly lower in patients who received iron chelation before transplantation (CIRs of TRM at 50, 100 days; 0.3, 1.8%). CONCLUSIONS:
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Authors | Seom Gim Kong, Seri Jeong, Sangjin Lee, Jee-Yeong Jeong, Da Jung Kim, Ho Sup Lee |
Journal | BMC cancer
(BMC Cancer)
Vol. 21
Issue 1
Pg. 177
(Feb 18 2021)
ISSN: 1471-2407 [Electronic] England |
PMID | 33602150
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- Databases, Factual
- Female
- Graft vs Host Disease
(etiology, mortality, pathology)
- Hematopoietic Stem Cell Transplantation
(adverse effects, methods, mortality)
- Humans
- Infant
- Infant, Newborn
- Leukemia, Myeloid, Acute
(mortality, pathology, therapy)
- Male
- Middle Aged
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(mortality, pathology, therapy)
- Republic of Korea
(epidemiology)
- Retrospective Studies
- Risk Factors
- Survival Analysis
- Time Factors
- Tissue Donors
- Transplantation, Homologous
- Young Adult
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