Abstract | BACKGROUND: METHODS: A total of 304 patients with AGC were retrospectively reviewed. SDR only was selected as a potential prognostic marker for the subsequent studies in this study. Based on the cut-off value of the SDR, the patients were divided into high-SDR and low-SDR groups and investigated for their clinicopathological features, first-line chemotherapy effects and clinical outcomes. RESULTS: The cut-off value based on the SDR was 282.22, and the patients were divided into low-SDR (SDR ≤ 282.22) and high-SDR (SDR > 282.22) groups. The disease control rate was higher in the high-SDR group than in the low-SDR group (91.1% vs. 82.3%; P = 0.036). Patients with a high SDR had a longer median PFS and OS than those with a low SDR (PFS: 206.0 vs. 134.0 days, P < 0.001; OS: 435.0 vs. 295.5 days, P < 0.001). The SDR was an independent prognostic indicator in the multivariable analysis of PFS (P < 0.001) and OS (P = 0.004). In subgroup analyses, among the patients with normal sodium and D-dimer levels, SDR was still a reliable prognostic indicator of PFS and OS in patients with AGC (all P ≤ 0.001). CONCLUSIONS:
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Authors | Liqun Zhang, Guilin Yu, Zhuo Wang, Fang Li, Guohua Zhao, Dan Zhao |
Journal | American journal of translational research
(Am J Transl Res)
Vol. 13
Issue 2
Pg. 792-802
( 2021)
ISSN: 1943-8141 [Print] United States |
PMID | 33594327
(Publication Type: Journal Article)
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Copyright | AJTR Copyright © 2021. |