A total of 556 subjects were included, comprising 279 women (50.2%) and 277 men (49.8%).
Metabolic syndrome was diagnosed in 236 subjects (42.4%), and the mean MFG-E8 level of subjects with
metabolic syndrome was significantly higher than that of subjects without
metabolic syndrome (P<0.001). MFG-E8 level was significantly correlated with all
metabolic syndrome components and pulse wave velocity (all P<0.05). Subjects were categorized into two groups according to the best MFG-E8 cut-off value as follows: group 1, MFG-E8 level <4,745.1 pg/mL (n=401, 72.1%); and group 2, MFG-E8 level ≥4,745.1 (n=155, 27.9%). At baseline,
metabolic syndrome in group 2 was significantly more prevalent than in group 1 (63.9% vs. 34.2%, P<0.001). During median follow-up of 17 months,
metabolic syndrome developed in 122 (38.1%) subjects among 320 subjects without it at baseline. The incidence of
metabolic syndrome in group 2 was significantly higher than that in group 1 (55.4% vs. 34.5%, P=0.003). On multivariate analysis, MFG-E8 level ≥4,745.1 pg/mL was an independent predictor for diagnosis and development of
metabolic syndrome after adjusting other factors (all P<0.05).
CONCLUSION: