Abstract | OBJECTIVE: To evaluate the clinical outcomes at age 1.5 ± 0.5 years of infants with vitamin B12 deficiency identified by newborn screening (NBS). STUDY DESIGN: Prospective multicenter observational study on health outcomes of 31 infants with vitamin B12 deficiency identified by NBS. Neurodevelopment was assessed by the Denver Developmental Screening Test. RESULTS: In 285 862 newborns screened between 2016 and 2019, the estimated birth prevalence of vitamin B12 deficiency was 26 in 100 000 newborns, with high seasonal variations (lowest in summer: 8 in 100 000). Infants participating in the outcome study (N = 31) were supplemented with vitamin B12 for a median (range) of 5.9 (1.1-16.2) months. All achieved age-appropriate test results in Denver Developmental Screening Test at age 15 (11-23) months and did not present with symptoms characteristic for vitamin B12 deficiency. Most (81%, n = 25) mothers of affected newborns had a hitherto undiagnosed (functional) vitamin B12 deficiency, and, subsequently, received specific therapy. CONCLUSIONS:
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Authors | Ulrike Mütze, Magdalena Walter, Mareike Keller, Gwendolyn Gramer, Sven F Garbade, Florian Gleich, Dorothea Haas, Roland Posset, Sarah C Grünert, Julia B Hennermann, Eva Thimm, Junmin Fang-Hoffmann, Steffen Syrbe, Jürgen G Okun, Georg F Hoffmann, Stefan Kölker |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 235
Pg. 42-48
(08 2021)
ISSN: 1097-6833 [Electronic] United States |
PMID | 33581104
(Publication Type: Journal Article, Comment)
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Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adolescent
- Child, Preschool
- Female
- Humans
- Infant
- Infant, Newborn
- Neonatal Screening
- Outcome Assessment, Health Care
- Pregnancy
- Prospective Studies
- Vitamin B 12
- Vitamin B 12 Deficiency
(diagnosis, drug therapy, epidemiology)
- Vitamins
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