Severe
burns trigger the stress response, cause different degrees of damage to the body, and participate in the occurrence and development of immune dysfunction and hypermetabolism after
burn. Rational application of
analgesic and
sedative drugs is the major method of inhibiting the severe
burn-induced stress response, which can alleviate the organ damages and reduce the incidence of
burn sepsis. Furthermore, integrated approaches including
wound management, infection control,
nutritional support, and gastrointestinal tract protection, as well as sleep management, etc., collectively contribute to the alleviation of stress response after
burn injury. To further improve the success rate of severe
burn treatment, it is essential to study the changes of various stresses, endocrine
hormones and immune patterns in patients with severe
burn, to explore the mechanism and regulation of
burn-induced hypermetabolism, and to reach a consensus on sedation and
analgesia strategy, the management of stress response and hypermetabolism after severe
burns.