Recent progress in nanoformulations of cabazitaxel.

Abstract

The antitumor efficacy of various paclitaxel (PTX) and docetaxel (DTX) formulations in clinical applications is seriously affected by drug resistance. Cabazitaxel, a second-generation taxane, exhibits greater anticancer activity than paclitaxel and docetaxel and has low affinity for the P-glycoprotein (P-gp) efflux pump because of its structure. Therefore, cabazitaxel has the potential to overcome taxane resistance. However, owing to the high systemic toxicity and hydrophobicity of cabazitaxel and the instability of its commercial preparation, Jevtana®, the clinical use of cabazitaxel is restricted to patients with metastatic castration-resistant prostate cancer (mCRPC) who show progression after docetaxel-based chemotherapy. Nanomedicine is expected to overcome the limitations associated with cabazitaxel application and surmount taxane resistance. This review outlines the drug delivery systems of cabazitaxel published in recent years, summarizes the challenges faced in the development of cabazitaxel nanoformulations, and proposes strategies to overcome these challenges.

• Authors: Yu Chen, Yue Pan, Danrong Hu, Jinrong Peng, Ying Hao, Meng Pan, Liping Yuan, Yongyang Yu, Zhiyong Qian
• Journal: Biomedical materials (Bristol, England) (Biomed Mater) (Feb 05 2021) ISSN: 1748-605X [Electronic] England
• PMID: 33545700 (Publication Type: Journal Article)
• Copyright: © 2021 IOP Publishing Ltd.