Prediction Model for Gastric Cancer With DNA Mismatch Repair Deficiency.

Abstract

BACKGROUND/AIM:

DNA mismatch repair (MMR) deficiency has received increasing attention as a biomarker of anti-PD-1 treatments of solid tumors including gastric cancer (GC). However, efficient screening has not been established.

PATIENTS AND METHODS:

A total of 513 patients were tested for the expression of MMR proteins by immunohistochemistry to identify MMR deficient GC. Development of a prediction model was attempted using the common clinicopathological features.

RESULTS:

In total, 11% (57/513) of the patients showed loss of expression of either one or more MMR proteins (MMR protein deficiency; MMR-D). Multivariate analysis demonstrated that age (≥70 years), sex (female), tumor location (lower 1/3), depth invasion (low, T1/T2/T3), and absence of distant metastasis were significantly independent predictive factors of MMR-D GCs. The MMR-D GC probability estimated by the prediction model ranged from 0.4% to 62.2%, and the area under the curve of the receiver operating characteristics curve was 0.82 (95% confidence interval=0.75-0.87).

CONCLUSION:

Our prediction model can sufficiently and efficiently identify MMR-D GCs using clinical features.

• Authors: Okihide Suzuki, Tatsuro Yamaguchi, Minoru Fukuchi, Erito Mochiki, Tomio Arai, Kiwamu Akagi, Hideyuki Ishida
• Journal: Anticancer research (Anticancer Res) Vol. 41 Issue 2 Pg. 975-982 (Feb 2021) ISSN: 1791-7530 [Electronic] Greece
• PMID: 33517304 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• DNA-Binding Proteins
• G-T mismatch-binding protein
• MLH1 protein, human
• PMS2 protein, human
• Mismatch Repair Endonuclease PMS2
• MutL Protein Homolog 1

Topics

• Adult
• Aged
• Aged, 80 and over
• Area Under Curve
• Biomarkers, Tumor (metabolism)
• DNA Mismatch Repair
• DNA-Binding Proteins (deficiency)
• Female
• Humans
• Male
• Middle Aged
• Mismatch Repair Endonuclease PMS2 (deficiency)
• MutL Protein Homolog 1 (deficiency)
• Neoplasm Grading
• Neoplasm Invasiveness
• Sex Characteristics
• Stomach Neoplasms (metabolism, pathology)
• Tumor Burden
• Young Adult