Body composition in Japanese patients with psychiatric disorders: A cross-sectional study.

Abstract

AIM:

This study aimed to investigate body composition in Japanese patients with psychiatric disorders.

METHODS:

A cross-sectional study was conducted to assess the body composition in Japanese patients with psychiatric disorders and healthy controls. InBody470 was used to measure the body composition of the participants. For the primary analysis, measures of body composition between patients and healthy controls were compared. Moreover, the following patient subgroups were also compared with the healthy controls: (a) patients with psychotic disorders only, (b) patients with mood disorders only, (c) patients receiving antipsychotics, (d) patients receiving conventional mood stabilizers, (e) patients receiving antidepressants only but not any antipsychotics and/or mood stabilizers, and (f) patients receiving hypnotics/anxiolytics.

RESULTS:

This study included 205 individuals (105 patients and 100 healthy controls). It was found that patients had a significantly higher body mass index, waist-hip ratio, body fat mass, and percent body fat compared with the healthy controls. Moreover, significant differences were noted in the waist-hip ratio, body fat mass, and percent body fat between all patient subgroups other than patients receiving conventional mood stabilizers subgroup and healthy controls.

CONCLUSION:

This is the first cross-sectional study to examine body composition in Japanese patients with psychiatric disorders. No difference in the skeletal muscle volume was noted although patients had higher body fat than healthy controls. A longitudinal and large cohort study in the future, controlling for medication and diagnosis, will need to determine why body fat is increased in Japanese patients with psychiatric disorders.

• Authors: Taro Kishi, Makoto Okuya, Kenji Sakuma, Yohei Otaka, Eiichi Saitoh, Nakao Iwata
• Journal: Neuropsychopharmacology reports (Neuropsychopharmacol Rep) Vol. 41 Issue 1 Pg. 117-121 (03 2021) ISSN: 2574-173X [Electronic] United States
• PMID: 33506653 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsycho Pharmacology.

Chemical References

• Antidepressive Agents
• Hypnotics and Sedatives
• Tranquilizing Agents

Topics

• Adult
• Antidepressive Agents (therapeutic use)
• Body Composition (physiology)
• Body Fat Distribution
• Body Mass Index
• Cross-Sectional Studies
• Female
• Humans
• Hypnotics and Sedatives (therapeutic use)
• Japan (epidemiology)
• Male
• Mental Disorders (drug therapy)
• Middle Aged
• Mood Disorders (drug therapy)
• Psychotic Disorders (drug therapy)
• Tranquilizing Agents (therapeutic use)
• Waist-Hip Ratio
• Young Adult