Abstract | BACKGROUND:
Glutamine metabolism is considered an important metabolic phenotype of proliferating tumor cells. OBJECTIVE: METHODS: RESULTS: The expression levels of GLS (p < 0.001), SLC7A5 (p = 0.049), and SDHB (p = 0.007) were higher in ACN than in PCC, whereas the expression levels of SLC1A5 (p < 0.001) and SLC7A11 (p < 0.001) were higher in PCC than in ACN. In ACN, GLS positivity was associated with a higher Fuhrman grade (p = 0.009), and SLC1A5 positivity was associated with SDHB positivity (p = 0.004) and a clear cell proportion < 25% (p = 0.010). SDHB negativity was also associated with tumor cell necrosis (p = 0.007). In PCC, SLC7A11 positivity was associated with nonnorepinephrine type (p = 0.008). In Kaplan-Meier analysis, patients with GLS positivity (p = 0.039) and SDHB negativity (p = 0.005) had significantly shorter overall survival in ACN. In PCC patients with a GAPP score ≥ 3, GLS positivity (p = 0.001) and SDHB positivity (p = 0.001) were associated with shorter disease-free survival, whereas GLS positivity (p = 0.004) was also associated with shorter overall survival. CONCLUSIONS:
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Authors | Hye Min Kim, Ja Seung Koo |
Journal | Disease markers
(Dis Markers)
Vol. 2021
Pg. 8850990
( 2021)
ISSN: 1875-8630 [Electronic] United States |
PMID | 33505538
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Hye Min Kim and Ja Seung Koo. |
Chemical References |
- Amino Acid Transport Systems, Basic
- Biomarkers, Tumor
- Glutamate Dehydrogenase
- GLS protein, human
- Glutaminase
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Topics |
- Adrenal Gland Neoplasms
(genetics, metabolism, pathology)
- Adrenal Glands
(metabolism, pathology)
- Adult
- Aged
- Amino Acid Transport Systems, Basic
(genetics, metabolism)
- Biomarkers, Tumor
(genetics, metabolism)
- Female
- Glutamate Dehydrogenase
(genetics, metabolism)
- Glutaminase
(genetics, metabolism)
- Humans
- Male
- Middle Aged
- Pheochromocytoma
(genetics, metabolism, pathology)
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