Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma in Korea: three case reports.

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune paraneoplastic syndrome associated with ovarian teratomas. Most patients develop neurologic symptoms, including psychosis, memory deficits, seizures, or abnormal movements, and experience abdominal pain related to ovarian neoplasm. We present a case report of three patients diagnosed with anti-NMDAR encephalitis accompanied by ovarian teratomas at Ajou University Hospital in Korea. The patients demonstrated a different clinical course of the disease. However, upon diagnosis, all patients underwent surgical removal of the ovarian teratoma followed by intensive immunotherapy. The symptoms progressively improved following treatment. This is a case report of a rare autoimmune anti-NMDAR encephalitis associated with ovarian neoplasms, including immature teratoma.

• Authors: Jisun Lee, Seongwoo Kang, Hye Jin Chang, Yong Hee Lee, Joo-Hyuk Son, Tae Wook Kong, Suk-Joon Chang, Kyung Joo Hwang, Miran Kim
• Journal: Yeungnam University journal of medicine (Yeungnam Univ J Med) Vol. 38 Issue 4 Pg. 350-355 (Oct 2021) ISSN: 2384-0293 [Print] Korea (South)
• PMID: 33498105 (Publication Type: Case Reports)