Abstract | BACKGROUND AND AIMS: There is a general interest in understanding how the consumption of tea impacts cardiovascular function in individuals at risk of developing cardiovascular disease (CVD). The current review focuses on evidence from randomized controlled trials (RCTs) reporting on associations between tea consumption and endothelial function, in the primary and secondary prevention of coronary artery disease (CAD). METHODS: PubMed, EMBASE, and Google Scholar databases/search engines were used to identify eligible studies. Included studies had to report on the impact of tea supplementation of endothelial function or CAD related markers. In addition to flow-mediated dilation (FMD), makers of oxidative stress and inflammation such as oxidized low-density lipoprotein and C-reactive protein were considered as determinants of endothelial function. A total of 34 RCTs met the inclusion criteria, and these reported on the impact of tea consumption on endothelial function in individuals at risk of CVD or patients with CAD. RESULTS: CONCLUSIONS: The cumulative evidence also suggests that the development of epigallocatechin gallate as a nutraceutical or enriching foods with this bioactive compound could be a feasible strategy to improve endothelial function and lower CVD-risk. However, well-designed RCTs are still necessary to confirm long-term benefits of tea consumption on vascular health.
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Authors | Phiwayinkosi V Dludla, Bongani B Nkambule, Sithandiwe E Mazibuko-Mbeje, Tawanda M Nyambuya, Patrick Orlando, Sonia Silvestri, Fabio Marcheggiani, Ilenia Cirilli, Khanyisani Ziqubu, Fransina Ndevahoma, Vuyolwethu Mxinwa, Kabelo Mokgalaboni, Jacopo Sabbatinelli, Johan Louw, Luca Tiano |
Journal | Clinical nutrition ESPEN
(Clin Nutr ESPEN)
Vol. 41
Pg. 77-87
(02 2021)
ISSN: 2405-4577 [Electronic] England |
PMID | 33487310
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Coronary Artery Disease
(prevention & control)
- Dietary Supplements
- Humans
- Randomized Controlled Trials as Topic
- Secondary Prevention
- Tea
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