The intra-articular administration of triamcinolone hexacetonide in the treatment of osteoarthritis. Its effects in a naturally occurring canine osteoarthritis model.

Abstract

OBJECTIVE:

To evaluate the effect of an intra-articular (IA) administration of triamcinolone hexacetonide, compared with saline.

PATIENTS AND METHODS:

Forty (N = 40) hip joints were randomly assigned to a treatment group (THG, n = 20, receiving IA triamcinolone hexacetonide) and a control group (CG, n = 20, receiving IA saline). On treatment day (T0), and at 8, 15, 30, 90 and 180 days post-treatment, weight distribution, joint range of motion, thigh girth, digital thermography, radiographic signs, synovial fluid interleukin-1 and C-reactive protein levels were evaluated. Data from four Clinical Metrology Instruments was also gathered. Results were compared Repeated Measures ANOVA, with a Huynh-Feldt correction, Paired Samples T-Test or Wilcoxon Signed Ranks Test. A Kaplan-Meier test was performed to compare both groups, with p<0.05.

RESULTS:

Joints were graded as mild (65%), moderate (20%) and severe (15%). Patients of both sexes, with a mean age of 6.5±2.4 years and bodyweight of 26.7±5.2kg, were included. No differences were found between groups at T0. Comparing THG to CG, weight distribution showed significant improvements in THG from 8 (p = 0.05) up to 90 days (p = 0.01). THG showed lower values during thermographic evaluation in the Lt view (p<0.01). Pain and function scores also improved from 30 to 180 days. Increasing body weight, age, and presence of caudolateral curvilinear osteophyte corresponded to worse response to treatment. Results of the Kaplan Meier test showed significant differences between groups, with THG performing better considering several evaluations and scores.

CONCLUSION:

THG recorded significant improvements in weight-bearing and in with the considered CMIs, particularly pain scores. Lower thermographic values were registered in THG up to the last evaluation day. Age, sex, and radiographic findings did significantly influenced response to treatment.

• Authors: João C Alves, Ana Santos, Patrícia Jorge, Catarina Lavrador, L Miguel Carreira
• Journal: PloS one (PLoS One) Vol. 16 Issue 1 Pg. e0245553 ( 2021) ISSN: 1932-6203 [Electronic] United States
• PMID: 33471857 (Publication Type: Journal Article)

Chemical References

• Triamcinolone Acetonide
• triamcinolone hexacetonide

Topics

• Age Distribution
• Animals
• Body Weight
• Disease Models, Animal
• Dogs
• Female
• Injections, Intra-Articular
• Male
• Osteoarthritis, Hip (diagnostic imaging, drug therapy)
• Sex Distribution
• Tomography, X-Ray Computed
• Triamcinolone Acetonide (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)