Combined Use of Immunoreactivities of RIG-I with Efp/TRIM25 for Predicting Prognosis of Patients With Estrogen Receptor-positive Breast Cancer.

Abstract

BACKGROUND:

We previously identified estrogen-responsive finger protein (Efp) as an estrogen-induced gene, and showed that the positive immunoreactivity of Efp is a poor prognostic factor for patients with breast cancer. We also demonstrated that Efp has distinctive roles in innate immunity by activating pattern recognition receptor retinoic acid-inducible gene I (RIG-I). The clinical value of RIG-I protein expression in breast cancer had not been evaluated in relationship with patients' prognosis.

PATIENTS AND METHODS:

Tissue samples of estrogen receptor-positive invasive breast cancer were obtained from 145 female patients with breast cancer who underwent surgical treatment. Immunoreactivities of RIG-I and Efp were analyzed with the antibodies generated for the present study.

RESULTS:

Positive immunoreactivity of RIG-I was correlated with lower disease-free survival (P = .032) and was an independent poor prognostic factor (P = .043). RIG-I immunoreactivity was positively correlated with that of Efp (P = .0004). Patients with positive immunoreactivities of both RIG-I and Efp proteins were associated with a lower disease-free survival rate (P = .005).

CONCLUSIONS:

Positive immunoreactivity of RIG-I has clinical significance as a poor prognostic factor in patients with estrogen receptor-positive breast cancer. A positive correlation of RIG-I and Efp immunoreactivities was observed, and the combination of their immunoreactivities can be used to predict patients' prognosis.

• Authors: Junichiro Sato, Kotaro Azuma, Keiichi Kinowaki, Kazuhiro Ikeda, Takuya Ogura, Yutaka Takazawa, Hidetaka Kawabata, Masanobu Kitagawa, Satoshi Inoue
• Journal: Clinical breast cancer (Clin Breast Cancer) Vol. 21 Issue 5 Pg. 399-407.e2 (10 2021) ISSN: 1938-0666 [Electronic] United States
• PMID: 33386231 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Transcription Factors
• Tripartite Motif Proteins
• TRIM25 protein, human
• Ubiquitin-Protein Ligases

Topics

• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (metabolism, pathology)
• Cell Line, Tumor
• Female
• Humans
• Prognosis
• Transcription Factors (metabolism)
• Tripartite Motif Proteins (metabolism)
• Ubiquitin-Protein Ligases (metabolism)