In Vivo Regenerable Cerium Oxide Nanozyme-Loaded pH/H2O2-Responsive Nanovesicle for Tumor-Targeted Photothermal and Photodynamic Therapies.

Abstract

Photodynamic therapy (PDT) and photothermal therapies (PTTs) are both promising strategies for effective tumor therapy. However, the absence of O2 at tumor sites hinders the sustained response of photosensitizers. Here, we develop a recycled cerium oxide (CeO2) catalase nanozyme-loaded hyaluronic acid nanovesicle to address the hypoxic tumor microenvironments and targeted delivery of the photosensitizers [indocyanine green (ICG)] to tumors. A polysaccharide complex effectively modifies the surface of a polyethylenimine phenylboronic acid nanostructure to achieve the CeO2 nanozyme-loading nanovesicles that exhibit both tumor-targeted enhancement and an improved hypoxic microenvironment. Also, the hydrogen peroxide responsiveness and acid-sensitive cleavage of phenylboronic acid specifically disintegrate the ICG/nanozyme coloaded nanovesicles in the tumor microenvironment. The in vitro synergistic tests and tumor suppression rate tests indicated that the cerium oxide nanozyme significantly improves the outcomes of PDT via cerium-element valence state recycling and hypoxia improvement, thus enhancing the tumor suppression efficiency. This pH/H2O2-responsive nanozyme/ICG codelivery system provides a good carrier model for improving the tumor microenvironment and increasing the efficiency of tumor-targeted PTT and PDT therapies.

• Authors: Li Zeng, Hui Cheng, Yuwei Dai, Zhipeng Su, Chengde Wang, Lei Lei, Deqing Lin, Xingyi Li, Hao Chen, Kelong Fan, Shuai Shi
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 13 Issue 1 Pg. 233-244 (Jan 13 2021) ISSN: 1944-8252 [Electronic] United States
• PMID: 33373178 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Photosensitizing Agents
• Reactive Oxygen Species
• Cerium
• ceric oxide
• Hyaluronic Acid
• Hydrogen Peroxide
• Indocyanine Green

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Catalysis
• Cell Line, Tumor
• Cerium (chemistry, therapeutic use, toxicity)
• Female
• Humans
• Hyaluronic Acid (chemistry, toxicity)
• Hydrogen Peroxide
• Hydrogen-Ion Concentration
• Indocyanine Green (therapeutic use)
• Infrared Rays
• Mice, Inbred BALB C
• Nanoparticles (chemistry, toxicity)
• Neoplasms (drug therapy, metabolism)
• Photochemotherapy
• Photosensitizing Agents (therapeutic use)
• Photothermal Therapy
• Reactive Oxygen Species (metabolism)
• Tumor Microenvironment (drug effects)
• Mice