Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients.

Abstract

Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 infection is the acute respiratory distress syndrome (ARDS) caused by the hyperinflammatory response (commonly called cytokine storm) of the lung macrophages. Studies showed that Vitamin D deficiency increases the severity of the ARDS in COVID-19 infection. We discuss here how the vitamin D supplementation may influence macrophage and myeloid-derived suppressor cells (MDSCs) inflammatory response, subdue the hyperinflammatory response, and lessen the ARDS in COVID-19 patients.

• Authors: Malgorzata Kloc, Rafik M Ghobrial, Agnieszka Lipińska-Opałka, Agata Wawrzyniak, Robert Zdanowski, Boleslaw Kalicki, Jacek Z Kubiak
• Journal: Cellular immunology (Cell Immunol) Vol. 360 Pg. 104259 (02 2021) ISSN: 1090-2163 [Electronic] Netherlands
• PMID: 33359760 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Receptors, Calcitriol
• Vitamins
• Vitamin D

Topics

• Animals
• COVID-19 (complications, immunology, pathology)
• Child
• Humans
• Inflammation (drug therapy, immunology, pathology, prevention & control)
• Lung (immunology, pathology)
• Macrophages (immunology, metabolism)
• Myeloid-Derived Suppressor Cells (immunology, metabolism)
• Receptors, Calcitriol (metabolism)
• Respiratory Distress Syndrome (drug therapy, immunology, pathology, prevention & control)
• Vitamin D (administration & dosage)
• Vitamins (administration & dosage)
• COVID-19 Drug Treatment