Magnetic polymeric nanobubbles with optimized core size for MRI/ultrasound bimodal molecular imaging of prostate cancer.

Abstract

Aim: To design MRI/ultrasound (US) dual modality imaging probes with optimized size for prostate cancer imaging by targeting prostate-specific membrane antigen (PSMA). Materials & methods: The PSMA-targeting polypeptide-nanobubbles (PP-NBs) with core size of 400 and 700 nm were fabricated and evaluated. Results: With excellent physical property and specificity, PP-NBs of both core size could image PSMA expression in prostate cancer xenografts. Particularly, 400 nm PP-NBs generated higher PSMA-specific MRI/US dual modality contrast enhancement than 700 nm PP-NBs in correlation with histopathologic findings. Conclusion: Benefit from the smaller core size, 400 nm PP-NBs had higher permeability and specificity than 700 nm PP-NBs, hence producing better PSMA-specific MRI/US dual modality imaging.

• Authors: Yunkai Zhu, Ying Sun, Weiyong Liu, Wenbin Guan, Huanhuan Liu, Yourong Duan, Yaqing Chen
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 15 Issue 30 Pg. 2901-2916 (12 2020) ISSN: 1748-6963 [Electronic] England
• PMID: 33300812 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Cell Line, Tumor
• Humans
• Magnetic Resonance Imaging
• Male
• Molecular Imaging
• Prostatic Neoplasms (diagnostic imaging)
• Ultrasonography