Clinical Significance and Role of TK1, CEA, CA 19-9 and CA 72-4 levels in Diagnosis of Colorectal Cancers.

Abstract

To explore the diagnostic value, pre-operative serum thymidine kinase 1(TK1), CEA, CA 19-9 and CA 72-4 levels were measured in 106 patients with colorectal carcinoma (53 colon and 53 rectal carcinoma patients) and 53 healthy controls. Sandwich Elisa, biotin-labeled antibody kit was used for TK1, and other tumor markers were measured using electro-chemiluminescence. Serum TK1 levels were significantly higher in CRC than in healthy controls (p <0.05) and showed significant associations with tumor stage, histopathological grade, lymph node status and metastasis (p <0.01). TK1 showed the highest (0.824-0.862) area under receiver operating characteristics curve (AUC) in comparison to other markers, and the AUC of the panel of combination tests performed even better (0.935-0.952). Significant variation was observed between the single biomarker test and their combination (Z test, p <0.01) and the Hosmer-Lemeshow test showed an adequate model of calibration. The algorithm based on combination of TK1, CEA, CA19-9 and CA72-4 can improve the diagnostic efficiency in CRC patients.<br />.

• Authors: Swarnima Singh, Rakesh Kumar, Uday Kumar, Rekha Kumari
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 21 Issue 11 Pg. 3133-3136 (Nov 01 2020) ISSN: 2476-762X [Electronic] Thailand
• PMID: 33247667 (Publication Type: Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• CA-19-9 Antigen
• CA-72-4 antigen
• Carcinoembryonic Antigen
• Thymidine Kinase
• thymidine kinase 1

Topics

• Adult
• Antigens, Tumor-Associated, Carbohydrate (blood)
• Biomarkers, Tumor (blood)
• CA-19-9 Antigen (blood)
• Carcinoembryonic Antigen (blood)
• Case-Control Studies
• Colorectal Neoplasms (blood, diagnosis)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Prognosis
• Thymidine Kinase (blood)