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Co-expression of Epstein-Barr virus-encoded RNA1 and viral latent membrane protein 1 in osteosarcoma: A novel insight of predictive markers.

Abstract
Epstein-Barr virus is an etiologic agent of several malignancies. In this study, we explored the association of Epstein-Barr virus-encoded RNA1 and Epstein-Barr virus latent membrane protein 1 co-expression with osteosarcoma. Epstein-Barr virus-encoded RNA1 expression in tumor cells was quantified using reverse transcriptase polymerase chain reaction and in situ hybridization and Epstein-Barr virus latent membrane protein 1 expression was measured using immunohistochemistry staining. There was a statistically significant association between Epstein-Barr virus latent membrane protein 1 and Epstein-Barr virus-encoded RNA1 co-expression and characteristics of osteosarcoma such as nodal stage (p < 0.04), metastasis (p < 0.04), Ki67 index (p < 0.03), and tumor stage (p < 0.05). Co-expression of Epstein-Barr virus-encoded RNA1 and Epstein-Barr virus latent membrane protein 1 in tumors correlated with advanced osteosarcoma and indicated the aggressiveness of bone sarcoma.
AuthorsKeykhosro Mardanpour, Mahtab Rahbar, Sourena Mardanpour, Sidegheh Khazaei, Mansour Rezaei
JournalTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 42 Issue 11 Pg. 1010428320974247 (Nov 2020) ISSN: 1423-0380 [Electronic] Netherlands
PMID33234011 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • EBV-associated membrane antigen, Epstein-Barr virus
  • Epstein-Barr virus encoded RNA 1
  • RNA, Viral
  • Viral Matrix Proteins
Topics
  • Adolescent
  • Adult
  • Biomarkers, Tumor (metabolism)
  • Child
  • Epstein-Barr Virus Infections (mortality, pathology, virology)
  • Female
  • Herpesvirus 4, Human (physiology)
  • Humans
  • Iran (epidemiology)
  • Male
  • Osteosarcoma (mortality, pathology, virology)
  • RNA, Viral (genetics, metabolism)
  • Retrospective Studies
  • Survival Analysis
  • Viral Matrix Proteins (metabolism)
  • Young Adult

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