Is the atypical hemolytic uremic syndrome risk polymorphism in Membrane Cofactor Protein MCPggaac relevant in kidney transplantation? A case report.

Abstract

aHUS is a rare disease characterized by episodes of TMA that frequently progresses to CKD and often recurs after KT. The most frequent cause of aHUS is defective regulation of complement activation because of genetic anomalies. Eculizumab interrupts the process of TMA and improves renal function. We describe one female patient with aHUS who debuted in 2005 at 3-mo-old with extrarenal manifestations and progressed to end-stage kidney disease (ESKD) within a year. Her family history included several affected members with similar bad outcomes. Our patient carries a strong aHUS genetic predisposition consisting in a pathogenic gain-of-function mutation in complement factor B concurrent with the MCP aHUS risk haplotype MCPggaac. She received a kidney transplant in 2011 without eculizumab prophylaxis. The graft, which was negative for the MCPggaac risk haplotype, had an unexpected excellent evolution without aHUS recurrence. Different retrospective studies have shown that the risk of aHUS recurrence after KT correlates well with the genetic load of aHUS risk factors. Knowing important contribution of the MCPggaac risk haplotype to the risk of developing aHUS in Factor B mutations carriers, we speculate whether the absence of this polymorphism in the graft that our patient received may have decreased the risk of aHUS recurrence after KT.

• Authors: Ana Sánchez-Moreno, Francisco de la Cerda, Adela Rodríguez-Barba, Julia Fijo, Rafael Bedoya, Emilia Arjona, Santiago Rodríguez de Córdoba
• Journal: Pediatric transplantation (Pediatr Transplant) Vol. 25 Issue 3 Pg. e13903 (May 2021) ISSN: 1399-3046 [Electronic] Denmark
• PMID: 33217135 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2020 Wiley Periodicals LLC.

Chemical References

• CD46 protein, human
• Membrane Cofactor Protein

Topics

• Atypical Hemolytic Uremic Syndrome (genetics)
• Female
• Humans
• Infant
• Kidney Transplantation
• Membrane Cofactor Protein (genetics)
• Pedigree
• Polymorphism, Genetic
• Risk Assessment