A novel hydrogel sheet prevents postoperative pancreatic fistula in a rat model.

Abstract

AIM:

To evaluate the efficacy of a novel hydrogel sheet in preventing postoperative pancreatic fistula (POPF).

BACKGROUND:

Postoperative pancreatic fistula is a life-threatening complication. As no study has reported the use of hydrogel sheets in preventing POPF, their effectiveness for that purpose remains unclear.

METHODS:

A novel hydrogel sheet made of polyvinyl alcohol (PVA) was prepared by the freeze-thaw method. The pancreatic ducts and surrounding pancreatic parenchyma of rats were transected to induce a pancreatic fistula. Next, the sheet was attached to the transection site. Ascitic fluid amylase and lipase concentrations were measured. Neoveil® , a nonwoven polyglycolic acid (PGA) felt, is already clinically used as an absorbable reinforcing material at pancreatic transection sites. Neoveil® was used for comparison, as was VIEWGEL® , which is marketed as a wound dressing.

RESULTS:

The hydrogel sheet remained in place 48 hours postoperatively. The ascitic amylase concentrations in the control, VIEWGEL® -treated, Neoveil® -treated, and hydrogel-treated rats, respectively, were 4992.4 ± 5355.7, 1068.4 ± 269.1, 730.2 ± 425.2, and 303.1 ± 240.1 IU/L; the ascitic lipase concentrations were 2279.8 ± 3395.2, 169.5 ± 100.6, 90.4 ± 71.0, and 86.8 ± 59.8 IU/L. The ascitic amylase and lipase levels were significantly lower in the hydrogel group than in the other groups (P < .05).

CONCLUSIONS:

This novel hydrogel sheet effectively prevents pancreatic fistulas and has promising clinical application potential.

• Authors: Akira Kemmochi, Takafumi Tamura, Yoshio Shimizu, Yohei Owada, Yusuke Ozawa, Katsuji Hisakura, Tatsuya Oda, Yayoi Kawano, Takehisa Hanawa, Nobuhiro Ohkohchi
• Journal: Journal of hepato-biliary-pancreatic sciences (J Hepatobiliary Pancreat Sci) Vol. 28 Issue 2 Pg. 192-201 (Feb 2021) ISSN: 1868-6982 [Electronic] Japan
• PMID: 33179402 (Publication Type: Journal Article)
• Copyright: © 2020 The Authors. Journal of Hepato-Biliary-Pancreatic Sciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Hepato-Biliary-Pancreatic Surgery.

Chemical References

• Hydrogels
• Amylases

Topics

• Amylases
• Animals
• Hydrogels
• Pancreas (surgery)
• Pancreatic Ducts
• Pancreatic Fistula (etiology, prevention & control)
• Postoperative Complications
• Rats