Prostaglandins A (PGA)

(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid (PGA(1)); (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid (PGA(2)); (5Z,13E,15S,17Z)-15-hydroxy-9-oxoprosta-5,10,13,17-tetraen-1-oic acid (PGA(3)). A group of naturally occurring secondary prostaglandins derived from PGE; PGA(1) and PGA(2) as well as their 19-hydroxy derivatives are found in many organs and tissues.

Also Known As:

Networked: 774 relevant articles (98 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gottlieb, Alice B: 8 articles (08/2013 - 05/2003)
2.	Sung, Moon-Hee: 7 articles (06/2015 - 04/2012)
3.	Sasaki, Hitoshi: 6 articles (11/2014 - 11/2011)
4.	Chun, Jeong-Hoon: 5 articles (12/2015 - 11/2009)
5.	Park, Jungchan: 5 articles (12/2015 - 11/2009)
6.	Gottlieb, A B: 5 articles (10/2015 - 06/2001)
7.	Kurosaki, Tomoaki: 5 articles (11/2014 - 11/2011)
8.	Kodama, Yukinobu: 5 articles (04/2014 - 11/2011)
9.	Smolen, Josef S: 4 articles (01/2016 - 09/2012)
10.	Aletaha, Daniel: 4 articles (01/2016 - 09/2012)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 12/01/2013 - "These results, which were the primary efficacy variables, demonstrated superior efficacy in the active study group for both overall improvement of plaque psoriasis (by PGA) and in the individual psoriasis lesion (by TLSS) designated at baseline as the most severely involved plaque (target lesion). " 10/01/2015 - "Clinical assessments included the proportion of patients achieving a Physician's Global Assessment of cleared/minimal (PGA 0/1), at least 75% improvement in Psoriasis Area and Severity Index (PASI 75), and at least 90% in PASI (PASI 90). " 07/09/2015 - "The primary end point was the proportion of patients with a Physician's Global Assessment (PGA) score of 0 (indicating cleared psoriasis) or 1 (indicating minimal psoriasis) at week 16. " 03/01/2015 - "At baseline, the patient's Psoriasis Area and Severity Index (PASI) was 12.2, and Physician's Global Assessment (PGA) score was 3. After 8 weeks of treatment, the patient achieved 97% improvement in PASI. " 08/01/2013 - "Subgroup analyses (t- test) were performed to compare mean DLQI improvement between patients who achieved and did not achieve clinical response (Physician's Global Assessment [PGA] 0/1 and at least a 75% improvement in the Psoriasis Area and Severity Index [PASI 75]) at weeks 10 and 26. "
2.	Pain (Aches) 06/01/2014 - "At 12 months, EGA, swollen joint count, and inflammatory marker values were not different, but pain visual analog scale and tender joint count were significantly higher in the higher PGA group, and the Health Assessment Questionnaire improved less. " 04/01/2014 - "SFTs, patient VAS and PGA scores for pain improved significantly from baseline in both groups with significantly greater improvements in the MSUS-guided group (44 shoulders) compared to the palpation-guided group (46 shoulders) in all parameters at 6 (p < 0.01) and 12 weeks (p < 0.05). " 12/01/2003 - "ESR, CRP, alpha(2) globulin, pain, PGA, MST, myalgia, MT, and EUL showed significant improvement (p<0.0001) at week 24 compared with week 0. " 10/01/2012 - "Increased pain (OR=1.28), EGA (OR=1.10) and discrepancy towards higher PGA than EGA (OR=1.28) could explain PGA failure to reach remission. " 01/01/2005 - "Pre-planned primary efficacy outcome measures included the core continuous variables pain relief and improved physical function measured by the Western Ontario and McMaster Universities (WOMAC) LK3.1 OA Index, and improved patient global assessment (PGA). "
3.	Neoplasms (Cancer) 04/01/2015 - "The in vivo efficacy of γ-PGA was tested in a mouse tumor model where both arms of adaptive immunity (humoral and cell-mediated) were found to be significantly enhanced in the presence of γ-PGA, indicating efficient priming of B and T cells. " 03/01/2014 - "The gradual release of P-R8 from P-R8-DOX/PGA may improve the therapeutic efficacy of water-soluble based nanomedicines for the treatment of solid lung tumors." 01/01/2015 - "These anti-cancer functions of PGA make it a promising compound for future study. " 12/01/1984 - "The purpose of these studies was to characterize the effect of the new anticancer preparation, 5-fluorouracil-polyglycolic acid-composite (F-PGA needle), on experimental tumors and in patients with solid tumors. " 10/01/2015 - "To accurately reflect the tumor-associated genomic abnormality burden in plasma, we developed a new scoring algorithm, plasma genomic abnormality (PGA) score, by summarizing absolute log2 ratios in most variable genomic regions. "
4.	Infection 01/01/2015 - "This study indicates that the AmB-PGA preparation could be a promising treatment for various fungal infections. " 07/01/2004 - "In one study, 3.5% SA or 1% SA with 3.5% PGA was compared with controls 15 min after application to assess the efficacy of the inactivation of virus and prevention of infection. " 01/01/2014 - "This study demonstrates the capacity of HM-γ-PGA treatment to significantly protect murine macrophage cells (RAW 264.7 cells) against NDV infection. " 07/01/2015 - "Of 17 patients treated with γ-PGA, only 12 patients who had a high-risk HPV infection were included in the analysis. " 01/01/2015 - "Our findings suggest that γ-PGA hydrolase genes might have spread across microbial genomes via horizontal exchanges rather than via phage infection. "
5.	Rheumatic Diseases (Rheumatism) 06/01/2012 - "The provisional ACR/European League Against Rheumatism (EULAR) definition of remission in RA requires a score of ≤1 on the patient global assessment (PGA, 0-10 scale). " 11/01/2000 - "To determine which activity indices better correlate with assessor's (AGA) and patient's (PGA) global assessment of disease activity and to compare the improvement with American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) criteria and their association with PGA and AGA of overall improvement. " 02/01/2010 - "Four definitions of good clinical response were used: > or =50% improvement in American College of Rheumatology response criteria (ACR50), good response according to European League Against Rheumatism (EULAR) guidelines, a > or =3-grade improvement in Physician Global Assessment of psoriasis (PGA) and a > or =50% improvement in the Nail Psoriasis Severity Index (NAPSI). " 01/01/2014 - "The American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria for rheumatoid arthritis (RA) are more stringent than index-based criteria, making it more difficult to achieve a patient's global assessment (PGA) than an evaluator's global assessment (EGA). " 05/01/1993 - "In patients with a serum PgA below 17 micrograms/l, normal serum gastrin levels (< 90 ng/l) as an indication of combined severe atrophy of antrum and corpus, were found in 1/13 patients with RA, in 3/11 with other rheumatic diseases and 2/12 with chronic non-rheumatic diseases (NS). "

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3.	ametantrone (HAQ)
4.	adalimumab (Humira)
5.	XP-828l
6.	Timolol (Blocadren)
7.	Immunoglobulin A (IgA)
8.	Gastrins
9.	monoclonal antibody CNTO 1275 (CNTO 1275)
10.	Diclofenac (SR 38)

Related Therapies and Procedures

1.	Oral Administration
2.	Sutures (Suture)
3.	Stents
4.	Oral Surgery (Maxillofacial Surgery)
5.	Glossectomy