High-Dietary Fiber Intake Alleviates Antenatal Obesity-Induced Postpartum Depression: Roles of Gut Microbiota and Microbial Metabolite Short-chain Fatty Acid Involved.
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| Abstract |
Antenatal obesity increases the risk of postpartum depression. Previous research found that dietary fiber supplementation could alleviate mental behavioral disorders. The present study aims to uncover the effects of high-dietary fiber intake on high-fat diet (HFD)-induced depressive-like behaviors and its underlying mechanism. Female C57BL6/J mice were fed with HFD to establish an antenatal obese model. A high-dietary fiber intake (inulin, 0.037 g/kcal) significantly attenuated cognitive deficits and depressive-like behaviors in the maternal mice after the offspring weaning. High-dietary fiber intake upregulated the expression of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) and suppressed neuroinflammation. Furthermore, high-dietary fiber intake restructured the gut microbiome and elevated the formation of short-chain fatty acids (SCFAs). Correlation analysis indicated that the increase in microbes such as Lactobacillus and S24-7, and SCFAs' levels were positively correlated with behavioral improvements. In conclusion, high-dietary fiber intake is a promising nutritional intervention strategy to prevent antenatal obesity-induced behavioral disorders via a microbiota-gut-brain axis.
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| Authors | Zhigang Liu, Ling Li, Shaobo Ma, Jin Ye, Hongbo Zhang, Yitong Li, Ali Tahir Sair, Junru Pan, Xiaoning Liu, Xiang Li, Shikai Yan, Xuebo Liu |
| Journal | Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 68 Issue 47 Pg. 13697-13710 (Nov 25 2020) ISSN: 1520-5118 [Electronic] United States |
| PMID | 33151669 (Publication Type: Journal Article) |
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