Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population.

Abstract

AIMS:

Diabetes mellitus and hypertension are both complex diseases that are caused by interactions among multiple genetic and physiological factors. To investigate the association of common single-nucleotide polymorphisms (SNPs) of SUCNR1, GRK4 and CAMK1D genes with the susceptibility of the two diseases in a northern Chinese Han population.

METHODS:

36 SNPs were genotyped in 2304 clinical patients (1152 type 2 diabetes mellitus, 1152 essential hypertension) and 1152 health controls by Sequenom Mass-ARRAY RS1000.

RESULTS:

In this study, we found that BMI, blood press, pulse pressure, FBG, total cholesterol and triglycerides were associated with an increased risk of type 2 diabetes mellitus (T2DM) and essential hypertension (EH). Three SNPs (SUCNR1: rs73168929; GRK4: rs1557213; CAMK1D: rs17151584) significantly associated with the susceptibility of T2DM and EH at the same time. Also, the susceptibility genotypes of 3 SNPs were significantly correlated with liver and renal function parameters.

CONCLUSION:

To the best of our knowledge, the present study is the first to report that three SNPs (SUCNR1: rs73168929; GRK4: rs1557213; CAMK1D: rs17151584) contributed to the risk of T2DM and EH in a northern Chinese Han population. These results provide a favourable evidence for better understand of the underlying common mechanism of these two diseases.

• Authors: Bingxin Du, Xinhui Jia, Wenqi Tian, Xueqin Yan, Ningning Wang, Defu Cai, Xueyan Li, Hao Zhang, Ming Jin, Nan Wu, Changchun Qiu, Qi Zhang
• Journal: Journal of diabetes and its complications (J Diabetes Complications) Vol. 35 Issue 1 Pg. 107752 (01 2021) ISSN: 1873-460X [Electronic] United States
• PMID: 33127268 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Receptors, G-Protein-Coupled
• SUCNR1 protein, human
• G-Protein-Coupled Receptor Kinase 4
• GRK4 protein, human
• CAMK1D protein, human
• Calcium-Calmodulin-Dependent Protein Kinase Type 1

Topics

• Asian People (genetics)
• Calcium-Calmodulin-Dependent Protein Kinase Type 1
• Case-Control Studies
• China (epidemiology)
• Diabetes Mellitus, Type 2 (epidemiology, genetics)
• Essential Hypertension
• G-Protein-Coupled Receptor Kinase 4
• Genetic Predisposition to Disease
• Genotype
• Humans
• Polymorphism, Single Nucleotide
• Receptors, G-Protein-Coupled