Abstract | BACKGROUND: OBJECTIVE: PNF is a neurophysiological approach that facilitates the stimulation of central and peripheral nervous systems. In this study, our aim was to assess the levels of BDNF as well as functional recovery before and after the intervention of PNF in patients with acute stroke. METHODS: A total of 208 patients with first time confirmed stroke were recruited and assessed for stroke severity, type, mini-mental state exam (MMSE), functional independence measure scale, and BDNF levels before and after PNF intervention. BDNF levels were also assessed in healthy individuals for control values. RESULTS: A significant decline in levels of BDNF was observed after in stroke. BDNF levels in patients (with different risk factors) with diabetes, hypertension and DM+ HTN, alcohol, and smoking history were 8.8 ± 4.04 ng/mL, 8.86 ± 4.68 ng/mL, 8.65 ± 3.26 ng/mL, 8.51 ± 4.26 ng/mL, and 8.9 ± 3.4 ng/mL, respectively. A decline in BDNF levels was observed in accordance with the severity of stroke in both ischemic and hemorrhagic stroke with the least level being in severe stroke (NIHSS >15 and ICH >3). Despite the type of stroke and the presence of risk factors, a significant improvement in BDNF levels and FIM scale scores was seen in all subjects who received PNF exercises. CONCLUSION: Thus, PNF is efficient in improving functional level in acute stroke irrespective of the type of stroke and risk factors.
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Authors | Poonam Chaturvedi, Ajai Kumar Singh, Vandana Tiwari, Anup Kumar Thacker |
Journal | Journal of family medicine and primary care
(J Family Med Prim Care)
Vol. 9
Issue 7
Pg. 3361-3369
(Jul 2020)
ISSN: 2249-4863 [Print] India |
PMID | 33102297
(Publication Type: Journal Article)
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Copyright | Copyright: © 2020 Journal of Family Medicine and Primary Care. |