Abstract | OBJECTIVE:
Chemotherapy induced peripheral neuropathy (CIPN) is an adverse effect of certain chemotherapy agents that can result in dose reductions, permanent nerve damage, and chronic pain. Although pharmacological agents have been studied in this setting, there is no standard of care for the prevention of CIPN. Thus, the objective of this systematic review is to assess the efficacy and safety of cryotherapy for the prevention of CIPN. DATA SOURCES: DATA SUMMARY: A total of 11 studies were included in the final assessment. Results of this systematic review indicate that the efficacy of cryotherapy in preventing CIPN is conflicting. This may be due to studies utilizing differing cryotherapy administration methods, study design, and including only a small number of patients. All included studies utilized cryotherapy with taxane-based chemotherapy treatments and cooling gloves and socks was the most common method of administration. Overall, cryotherapy was well-tolerated and no serious adverse effects were noted. CONCLUSIONS: Due to the absence of serious adverse effects, cryotherapy is a reasonable option to consider to prevent CIPN in patients receiving taxane-based chemotherapy. However, additional research is needed, including larger, better designed studies, to fully delineate the role of cryotherapy for CIPN.
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Authors | Andrea G Bailey, Jamie N Brown, Julia M Hammond |
Journal | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
(J Oncol Pharm Pract)
Vol. 27
Issue 1
Pg. 156-164
(Jan 2021)
ISSN: 1477-092X [Electronic] England |
PMID | 32955997
(Publication Type: Journal Article, Systematic Review)
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Chemical References |
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Topics |
- Antineoplastic Agents
(adverse effects)
- Cryotherapy
(methods)
- Humans
- Hypothermia, Induced
- Peripheral Nervous System Diseases
(chemically induced, therapy)
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