The adverse reaction of
Black Hairy Tongue (
BHT) caused by
linezolid is rare. We reports a case of
linezolid-induced
BHT, and reviews relevant literatures at home and abroad. It aims to provide a safe and reasonable basis for clinical medication use. A 14-year-old adolescent with
pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) developed a
rash and
pruritus due to
Vancomycin. Instead, the patient was given
linezolid 600mg q12h in injection during hospitalization and in
tablet after discharge. On the 14th day after injection and the second day after
oral administration the patient showed
BHT without other abnormal taste symptoms. But all the symptoms could be tolerated and he completed the
therapy course of
linezolid. Tongue symptoms completely disappeared on the 8th day after
drug withdrawal. Based on the Karch and Lasagna evaluation methods and the cause-and-effect evaluation methods of the WHO collaborating center for international
adverse drug reaction (ADR) monitoring, it is likely that this patient had a
BHT caused by
linezolid. The mean time of occurrence of
BHT was 14.36 days, and the mean time of symptom disappearance was 23.43 days after
drug administration. When
linezolid is prescribed to patients, especially those with atopy, the patient's tongue should be closely observed and good
oral hygiene is recommended.