Epsins in vascular development, function and disease.

Abstract

Epsins are a family of adaptor proteins involved in clathrin-dependent endocytosis. In the vasculature, epsins 1 and 2 are functionally redundant members of this family that are expressed in the endothelial cells of blood vessels and the lymphatic system throughout development and adulthood. These proteins contain a number of peptide motifs that allow them to interact with lipid moieties and a variety of proteins. These interactions facilitate the regulation of a wide range of cell signaling pathways. In this review, we focus on the involvement of epsins 1 and 2 in controlling vascular endothelial growth factor receptor signaling in angiogenesis and lymphangiogenesis. We also discuss the therapeutic implications of understanding the molecular mechanisms of epsin-mediated regulation in diseases such as atherosclerosis and diabetes.

• Authors: Sudarshan Bhattacharjee, Yang Lee, Bo Zhu, Hao Wu, Yabing Chen, Hong Chen
• Journal: Cellular and molecular life sciences : CMLS (Cell Mol Life Sci) Vol. 78 Issue 3 Pg. 833-842 (Feb 2021) ISSN: 1420-9071 [Electronic] Switzerland
• PMID: 32930806 (Publication Type: Journal Article, Review)

Chemical References

• Adaptor Proteins, Vesicular Transport
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factor Receptor-2

Topics

• Adaptor Proteins, Vesicular Transport (chemistry, metabolism)
• Atherosclerosis (metabolism, pathology)
• Endothelial Cells (cytology, metabolism)
• Humans
• Lymphangiogenesis
• Neoplasms (metabolism, pathology)
• Neovascularization, Pathologic
• Signal Transduction
• Vascular Endothelial Growth Factor A (metabolism)
• Vascular Endothelial Growth Factor Receptor-2 (metabolism)