Abstract | OBJECTIVE: METHODS: Approximately 9-10 years after pregnancy, hs-cTnI levels were measured for 339 women of the Preeclampsia Risk Evaluation in FEMales cohort, consisting of 177 women with a history of early-onset preeclampsia and 162 women with a previous uncomplicated index pregnancy. Associations were analyzed using several statistical tests and linear regression analysis. RESULTS: The median hs-cTnI levels (IQR) were 2.50 ng/l (2.30) in women with a history of early-onset preeclampsia and 2.35 ng/l (2.50) in women without a history of preeclampsia, P = 0.53. Among women with a history of early-onset preeclampsia, the hs-cTnI levels were higher in women who were hypertensive compared with their normotensive counterparts (medians 2.60 versus 2.30; P = 0.03). In addition, blood pressure levels increased with increasing hs-cTnI levels. CONCLUSION: We did not find a difference in hs-cTnI levels between women with and without a history of early-onset preeclampsia. Nonetheless, hs-cTnI levels were statistically significantly higher in current hypertensive women with a history of preeclampsia compared with their normotensive counterparts. Therefore, hs-cTnI levels might improve risk prediction for women at the highest risk of cardiovascular disease.
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Authors | Hella E C Muijsers, Dirk Westermann, Anna Birukov, Olivier W H van der Heijden, José T Drost, Kristin Kräker, Nadine Haase, Dominik N Müller, Florian Herse, Angela H E M Maas, Ralf Dechend, Tanja Zeller, Nel Roeleveld |
Journal | Journal of hypertension
(J Hypertens)
Vol. 38
Issue 10
Pg. 1948-1954
(10 2020)
ISSN: 1473-5598 [Electronic] Netherlands |
PMID | 32890270
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Blood Pressure
- Cohort Studies
- Female
- Humans
- Hypertension
(epidemiology)
- Pre-Eclampsia
(blood, epidemiology)
- Pregnancy
- Risk Factors
- Troponin I
(blood)
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