Abstract | BACKGROUND: Most cancer cells exhibit increased glycolysis and use this metabolic pathway cell growth and proliferation. Targeting cancer cells' metabolism is a promising strategy in inhibiting cancer cell progression. We used D- Mannoheptulose, a specific hexokinase inhibitor, to inhibit glycolysis to enhance the Newcastle disease virus anti- tumor effect. METHODS: RESULTS: The results showed synergistic cytotoxicity against breast cancer cells by combination therapy but no cytotoxic effect against normal cells. The effect was accompanied by apoptotic cell death and hexokinase downregulation and inhibition to glycolysis products, pyruvate, ATP, and acidity. CONCLUSIONS: The combination treatment showed safe significant tumor cell proliferation inhibition compared to monotherapies suggesting a novel strategy for anti- breast cancer therapy through glycolysis inhibition by hexokinase downregulation.
|
Authors | Ahmed Ghdhban Al-Ziaydi, Ahmed Majeed Al-Shammari, Mohammed I Hamzah, Haider Sabah Kadhim, Majid Sakhi Jabir |
Journal | Cancer cell international
(Cancer Cell Int)
Vol. 20
Pg. 420
( 2020)
ISSN: 1475-2867 [Print] England |
PMID | 32874134
(Publication Type: Journal Article)
|
Copyright | © The Author(s) 2020. |