Abstract | PROBLEM: Although not being recommended in guidelines, many physicians perform routine screening for thrombophilia in RM patients suspecting a higher prevalence in these patients. The aim of this study was to analyze the prevalence of inherited and acquired thrombophilia in a large cohort of RM patients. METHOD OF STUDY: RESULTS: An antiphospholipid syndrome (APLS) was only present in RM patients. Increased factor VIII concentration was significantly more prevalent in controls (RM vs controls: 5.8% vs 11.0%). None of the other thrombophilia did differ significantly between RM patients and controls. The meta-analysis revealed no significant difference in the occurrence of these thrombophilia between RM patients and controls. CONCLUSION: The prevalence of inherited thrombophilia does not differ between RM patients and controls. When analyzing rare events like thrombophilia, a high number of patients are needed to obtain reliable results, which might explain contradictory findings in previous studies analyzing small cohorts of RM patients. Despite being less prevalent than previously described, we still recommend screening for APLS as it is associated with severe pregnancy complications.
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Authors | Kilian Vomstein, Anna Herzog, Pauline Voss, Katharina Feil, Tamara Goeggl, Thomas Strowitzki, Bettina Toth, Ruben-Jeremias Kuon |
Journal | American journal of reproductive immunology (New York, N.Y. : 1989)
(Am J Reprod Immunol)
Vol. 85
Issue 1
Pg. e13327
(01 2021)
ISSN: 1600-0897 [Electronic] Denmark |
PMID | 32860294
(Publication Type: Journal Article, Meta-Analysis, Multicenter Study)
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Copyright | © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Antibodies, Anticardiolipin
- Antithrombins
- Lupus Coagulation Inhibitor
- Protein C
- anti-beta 2 glycoprotein I autoantibody
- factor V Leiden
- F8 protein, human
- Factor V
- Prothrombin
- Factor VIII
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Topics |
- Abortion, Habitual
(blood, epidemiology, genetics)
- Activated Protein C Resistance
- Adolescent
- Adult
- Antibodies, Anticardiolipin
(blood)
- Antithrombins
(blood)
- Case-Control Studies
- Factor V
(analysis)
- Factor VIII
(analysis)
- Female
- Humans
- Lupus Coagulation Inhibitor
(blood)
- Mutation
- Pregnancy
- Prevalence
- Protein C
(analysis)
- Prothrombin
(genetics)
- Thrombophilia
(blood, epidemiology, genetics)
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