Altered levels of circulating natural antibodies against VEGFR1-derived peptide in atherosclerosis.

Abstract

BACKGROUND:

Several lines of evidence have pointed to a protective role of natural antibodies in chronic diseases like atherosclerosis and cancer. Vascular endothelial growth factor receptor 1 (VEGFR1) and VEGFR2 are important regulators of angiogenesis and may be involved in the development of atherosclerosis. In this retrospective study, we developed an in-house enzyme-linked immunosorbent assay to assess whether natural IgG levels against VEGFR1 and the regulatory T cell markers CD25 and FOXP3 were associated with atherosclerosis.

METHODS:

A total of 218 patients with atherosclerosis and 200 healthy controls were enrolled. All patients had atherosclerotic carotid plaques. Carotid intima-media thickness was analyzed using a diagnostic ultrasound system.

RESULTS:

Plasma anti-VEGFR1 IgG levels were significantly lower in patients with atherosclerosis than control subjects. Decreased anti-VEGFR1 IgG levels were more obvious in male patients. Spearman correlation analysis showed no significant correlation between natural IgG levels and carotid intima-media thickness.

CONCLUSIONS:

Decreased levels of anti-VEGFR1 IgG may be involved in development of atherosclerosis and related conditions.

• Authors: Peng Wang, Siqi Liu, Zhenqi Wang, Huan Zhao, Xuan Zhang
• Journal: The Journal of international medical research (J Int Med Res) Vol. 48 Issue 8 Pg. 300060520948750 (Aug 2020) ISSN: 1473-2300 [Electronic] England
• PMID: 32811267 (Publication Type: Journal Article)

Chemical References

• Peptides
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factor Receptor-1

Topics

• Atherosclerosis
• Carotid Intima-Media Thickness
• Humans
• Male
• Peptides
• Retrospective Studies
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factor Receptor-1