Abstract | INTRODUCTION:
Vernal Keratoconjunctivitis is a chronic bilateral seasonally exacerbated allergy affecting the conjunctiva and cornea of children. As technology has advanced, newer medications have been developed for the control of the disease. PURPOSE: MATERIALS AND METHODS: Fifty patients of moderate, severe to very severe vernal keratoconjunctivitis were selected for the study. They were given cyclosporine 0.05% eye drops in loading dose followed by gradual tapering. Symptoms and signs were recorded at presentation, after two weeks, after four weeks, after two months and after three months. RESULTS:
Vernal keratoconjunctivitis, being a chronic disease showed marked improvement with immunomodulator therapy. There was significant improvement in the symptom and sign score initially, at the first follow up itself with symptom score reduction from median of mean of 2.4 to 0.6 (p=0.00) and a similar sign score reduction from 1.75 to 0.625 (p=0.00). There was gradually more improvement as therapy continued and the beneficial effects were maintained till the end point of the study at three months where median of mean symptom score was 0.4 (p=0.00) and similar sign score of 0.375 (p= 0.000). CONCLUSION:
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Authors | Kumudini Subedi, Binita Sharma, Sabina Shrestha |
Journal | Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
(Nepal J Ophthalmol)
Vol. 12
Issue 23
Pg. 39-47
(Jan 2020)
ISSN: 2091-0320 [Electronic] Nepal |
PMID | 32799238
(Publication Type: Journal Article)
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Copyright | © NEPjOPH. |
Chemical References |
- Immunosuppressive Agents
- Ophthalmic Solutions
- Cyclosporine
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Topics |
- Administration, Topical
- Child
- Conjunctiva
- Conjunctivitis, Allergic
(diagnosis, drug therapy)
- Cyclosporine
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Ophthalmic Solutions
- Treatment Outcome
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