CD204-positive monocytes and macrophages ameliorate septic shock by suppressing proinflammatory cytokine production in mice.

Abstract

Sepsis is defined as a life-threatening multiorgan dysfunction caused by dysregulated inflammatory response to infection. It remains the primary cause of death from infection if not diagnosed and treated promptly. Therefore, a better understanding of the mechanism for resolving inflammation is needed. Monocytes and macrophages play a pivotal role not only in the induction but also in the suppression of inflammation. However, a tissue-resident macrophage subset that regulates a hyperinflammatory state during sepsis has not been explored. Here we show that CD204+ monocytes and/or macrophages rescued mice from endotoxin-induced septic shock. Serum and tissue proinflammatory cytokine levels were significantly upregulated in the absence of these cells. This study provided evidence that CD204+ monocytes and/or macrophages ameliorate septic shock by suppressing proinflammatory cytokine production.

• Authors: Yoshimi Uchida, Gen Nishitai, Kenta Kikuchi, Takumi Shibuya, Kenichi Asano, Masato Tanaka
• Journal: Biochemistry and biophysics reports (Biochem Biophys Rep) Vol. 23 Pg. 100791 (Sep 2020) ISSN: 2405-5808 [Electronic] Netherlands
• PMID: 32793817 (Publication Type: Journal Article)
• Copyright: © 2020 The Authors.