To elucidate the regularities of adaptation of the representatives of class Mollicutes to antimicrobials and to identify the promising targets for eradication of
mycoplasma infections and contaminations the comparative analysis of the molecular basis of bacterial resistance to
antibiotics of different classes is needed. Previously, we presented the data on the whole-genome sequences of Acholeplasma laidlawii strains with different susceptibility to
ciprofloxacin (GenBank: LXYB00000000.1),
tetracycline (GenBank: NELO00000000.2) and
melittin (GenBank: NELN00000000.2) as well as the data on cell and extracellular vesicle
proteomes of
melittin-resistant A. laidlawii strain [1]. The lists of extracellular vesicle
proteins secreted by A. laidlawii strains with the increased resistance to
ciprofloxacin (PG8R10) and
tetracycline (PG8RTet) are presented here. The vesicle
proteome profiles were obtained by 1D SDS-PAGE and liquid chromatography-mass spectrometry.