Abstract | OBJECTIVE:
Pancreatic cancer and diabetes status have complex bilateral interactions; therefore, understanding their clinical features is essential for the clinical management of pancreatic cancer patients. We aimed to evaluate the diabetes status before diagnosis, after resection and until the time of recurrence in patients with resectable pancreatic cancer and to clarify the correlations among the clinical course of pancreatic cancer, operative procedure and diabetes status. METHODS: RESULTS: Among 115 pancreatic cancer patients who had normal glucose tolerance at the time of resection, 22 (19.1%) developed type 2 diabetes after resection. In a multivariate analysis, distal pancreatectomy was strongly associated with the development of postoperative diabetes. On the other hand, 74 pancreatic cancer patients had already been diagnosed with type 2 diabetes at the time of resection. During the follow-up period, 15 patients were noted to have diabetes resolution after resection; interestingly, the majority of these patients had newly diagnosed diabetes, which was defined as the diagnosis of diabetes within 3 months before resection. Moreover, newly diagnosed diabetes was an independent factor for diabetes resolution after resection. CONCLUSIONS:
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Authors | Ayako Shingyoji, Rintaro Mikata, Sadahisa Ogasawara, Yuko Kusakabe, Shin Yasui, Harutoshi Sugiyama, Izumi Ohno, Jun Kato, Shigetsugu Takano, Hideyuki Yoshitomi, Masayuki Ohtsuka, Naoya Kato |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 50
Issue 12
Pg. 1403-1411
(Dec 16 2020)
ISSN: 1465-3621 [Electronic] England |
PMID | 32761096
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected]. |
Chemical References |
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Topics |
- Aged
- Blood Glucose
(analysis)
- Diabetes Mellitus, Type 2
(complications, diagnosis, etiology, surgery)
- Female
- Humans
- Male
- Pancreatectomy
(adverse effects, methods)
- Pancreatic Neoplasms
(complications, pathology, surgery)
- Postoperative Complications
(diagnosis, etiology)
- Preoperative Period
- Retrospective Studies
- Risk Factors
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