Retinal Vasculometry Associations With Glaucoma: Findings From the European Prospective Investigation of Cancer-Norfolk Eye Study.

Abstract

PURPOSE:

To examine retinal vasculometry associations with different glaucomas in older British people.

DESIGN:

Cross-sectional study.

METHODS:

A total of 8,623 European Prospective Investigation into Cancer-Norfolk Eye study participants were examined, who underwent retinal imaging, ocular biometry assessment, and clinical ascertainment of ocular hypertensive or glaucoma status (including glaucoma suspect [GS], high-tension open-angle glaucoma [HTG], and normal-tension glaucoma [NTG]). Automated measures of arteriolar and venular tortuosity, area, and width from retinal images were obtained. MainOutcomeMeasures: Associations between glaucoma and retinal vasculometry outcomes were analyzed using multilevel linear regression, adjusted for age, sex, height, axial length, intraocular and systemic blood pressure, and within-person clustering, to provide absolute differences in width and area, and percentage differences in vessel tortuosity. Presence or absence of within-person-between-eye differences in retinal vasculometry by diagnoses were examined.

RESULTS:

A total of 565,593 vessel segments from 5,947 participants (mean age 67.6 years, SD 7.6 years, 57% women) were included; numbers with HTG, NTG, and GS in at least 1 eye were 87, 82, and 439, respectively. Thinner arterioles (-3.2 μm; 95% confidence interval [CI] -4.4 μm, -1.9 μm) and venules (-2.7 μm; 95% CI -4.9 μm, -0.5 μm) were associated with HTG. Reduced venular area was associated with HTG (-0.2 mm2; 95% CI -0.3 mm2, -0.1 mm2) and NTG (-0.2 mm2; 95% CI -0.3 mm2, -0.0 mm2). Less tortuous retinal arterioles and venules were associated with all glaucomas, but only significantly for GS (-3.9%; 95% CI -7.7%, -0.1% and -4.8%; 95% CI -7.4%, -2.1%, respectively). There was no evidence of within-person-between-eye differences in retinal vasculometry associations by diagnoses.

CONCLUSIONS:

Retinal vessel width associations with glaucoma and novel associations with vessel area and tortuosity, together with no evidence of within-person-between-eye differences in retinal vasculometry, suggest a vascular cause of glaucoma.

• Authors: Alicja R Rudnicka, Christopher G Owen, Roshan A Welikala, Sarah A Barman, Peter H Whincup, David P Strachan, Michelle P Y Chan, Anthony P Khawaja, David C Broadway, Robert Luben, Shabina A Hayat, Kay-Tee Khaw, Paul J Foster
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 220 Pg. 140-151 (12 2020) ISSN: 1879-1891 [Electronic] United States
• PMID: 32717267 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Crown Copyright © 2020. Published by Elsevier Inc. All rights reserved.

Topics

• Aged
• Biometry (methods)
• Cross-Sectional Studies
• Europe
• Female
• Glaucoma, Open-Angle (diagnosis, physiopathology)
• Humans
• Intraocular Pressure (physiology)
• Male
• Prospective Studies
• Retinal Vessels (diagnostic imaging)
• Tomography, Optical Coherence