Various animal models, especially rodents, are used to study
pain, due to the difficulty of studying it in humans. Many drugs that produce
analgesia have been studied and there is evidence among which
NSAIDs deserve to be highlighted.
Dexketoprofen (DEX) provides a broad antinociceptive profile in different types of
pain; therefore, this study was designed to evaluate the profile of antinociceptive potency in mice.
Analgesic activity was evaluated using the
acetic acid abdominal constriction test (writhing test), a chemical model of
visceral pain. Dose-response curves for i.p. DEX administration (1, 3, 10, 30 and 100 mg/kg), using at least six mice in each of at least five doses, was obtained before and 30 min after pre-treatment with different pharmacological agents. Pretreatment of the mice with
opioid receptor antagonists was not effective; however, the
serotonin receptor antagonist and
nitric oxide synthase inhibitor produce a significant increase in DEX-induced antinociception. The data from the present study shows that DEX produces antinociception in the chemical twisting test of mice, which is explained with difficulty by the simple inhibition of COX. This effect appears to be mediated by other mechanisms in which the contribution of the NO and
5-HT pathways has an important effect on DEXinduced antinociception.