The HLA-B*13:01 and the dapsone hypersensitivity syndrome in Korean and Asian populations: genotype- and meta-analyses.

Abstract

BACKGROUND:

The human leukocyte antigen (HLA)-B*13:01 was reported as an important risk factor for dapsone hypersensitivity syndrome (DHS) in Chinese and Thai populations.

RESEARCH DESIGN AND METHODS:

From the Korean nationwide registry, seven subjects with previous DHS were included. Their HLA allele/phenotype frequencies were compared with 8 dapsone-tolerant subjects recruited from a single institution, and general population (n = 485) in Korea. The authors also performed a meta-analysis with these data using previous Chinese and Thai studies.

RESULTS:

Among the seven DHS subjects, 85.7% presented with the HLA-B*13:01 allele. The HLA-C*03:04, HLA-DRB1*12:02 (both in linkage disequilibrium with HLA-B*13:01), and HLA-A*02:01 alleles were also presented in 85.7%, 71.4%, and 71.4%, respectively. Subjects with HLA-B*13:01 were susceptible to developing DHS compared to dapsone-tolerant controls (odds ratio [OR]: 73.667) and the Korean general population (OR: 139.500). HLA-C*03:04 (OR: 40.935), HLA-DRB*12:02 (OR: 36.613), and HLA-A*02:01 (OR: 5.862) showed similar results. In meta-analysis, HLA-B*13:01 was associated with dapsone-induced hypersensitivity (overall OR: 42.692), and subgroup analyses according to the control types demonstrated similar results (OR:43.694 and 41.866, respectively).

CONCLUSIONS:

Similar to previous Asian population studies, HLA-B*13:01 is significantly associated with the risk of DHS in Korea. These associations may be useful for preventing DHS and improving drug safety.

• Authors: Hye Jung Park, Jung-Won Park, Sae Hoon Kim, So-Yun Choi, Hee-Kyoo Kim, Chang-Gyu Jung, Min-Suk Yang, Dong Yoon Kang, Min-Kyoung Cho, Hyouk-Soo Kwon, Hye-Ryun Kang, Yong Won Lee, Allergy Work Group of KAAACI
• Journal: Expert opinion on drug safety (Expert Opin Drug Saf) Vol. 19 Issue 10 Pg. 1349-1356 (Oct 2020) ISSN: 1744-764X [Electronic] England
• PMID: 32700588 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• HLA-B13 Antigen
• Leprostatic Agents
• Dapsone

Topics

• Adult
• Aged
• Asian People (genetics)
• Child
• Dapsone (administration & dosage, adverse effects)
• Drug Hypersensitivity Syndrome (etiology, genetics)
• Female
• Genotype
• HLA-B13 Antigen (genetics)
• Humans
• Leprostatic Agents (administration & dosage, adverse effects)
• Male
• Middle Aged
• Registries
• Republic of Korea
• Risk Factors