Abstract | BACKGROUND: Concomitant administration of vaccines simplifies delivery. DTaP5-HB-IPV-Hib is a fully liquid, combination vaccine against 6 diseases. This study evaluated the compatibility of DTaP5-HB-IPV-Hib with 2 different meningococcus group C conjugate (MCC) vaccines in infants. METHODS: RESULTS: Per protocol analysis, MCC SPRs were 100 and 96.4 one month after the first dose, 100 and 99.1 after the second dose, and 100 and 97.3 after the third (booster) dose of MCC in the MCC-TT and MCC-CRM groups, respectively. One month after all 3 doses of DTaP5-HB-IPV-Hib, immunoglobulin G anti-polyribosylribitol phosphate SPRs (% ≥0.15 µg/mL) were 97.8 in the MCC-TT group and 100 in the MCC-CRM group; anti- hepatitis B antigen SPRs (% ≥10 mIU/mL) were 96.8 and 96.3 in the MCC-TT and MCC-CRM groups, respectively. All participants were seroprotected against diphtheria and tetanus (≥0.01 IU/mL) and poliovirus types 1, 2, and 3 (≥8 dilution), and seroresponse rates to all pertussis antigens were ≥90.4%. Two vaccine-related serious adverse events (transient severe abdominal pain and crying) occurred concomitantly in 1 participant in the MCC-CRM group. Adverse event rates were similar to other studies of DTaP5-HB-IPV-Hib, with pyrexia ≥38 °C in 10.9% of participants following any dose. CONCLUSIONS: DTaP5-HB-IPV-Hib can be effectively used in a 2-, 3-, and 4-month infant priming schedule when given with 2 doses of MCC.
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Authors | Jennifer L Oliver, Christine Sadorge, Florence Boisnard, Matthew D Snape, Richard Tomlinson, Rebecca Mann, Peter Rudd, Shyam Bhakthavalsala, Saul N Faust, Paul T Heath, Stephen M Hughes, Ray Borrow, Stéphane Thomas, Adam Finn |
Journal | Vaccine
(Vaccine)
Vol. 38
Issue 35
Pg. 5718-5725
(07 31 2020)
ISSN: 1873-2518 [Electronic] Netherlands |
PMID | 32654902
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020. Published by Elsevier Ltd. |
Chemical References |
- Antibodies, Bacterial
- Diphtheria-Tetanus-Pertussis Vaccine
- Haemophilus Vaccines
- Meningococcal Vaccines
- Poliovirus Vaccine, Inactivated
- Vaccines, Combined
- Vaccines, Conjugate
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Topics |
- Animals
- Antibodies, Bacterial
- Diphtheria-Tetanus-Pertussis Vaccine
- Haemophilus Vaccines
- Haemophilus influenzae type b
- Humans
- Infant
- Meningococcal Vaccines
- Poliovirus Vaccine, Inactivated
- Rabbits
- Serogroup
- Vaccines, Combined
- Vaccines, Conjugate
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