Oxidative Stress in Cancer.

Abstract

Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting transformation/proliferation of cancer cells or causing cell death. To accommodate high ROS levels, tumor cells modify sulfur-based metabolism, NADPH generation, and the activity of antioxidant transcription factors. During initiation, genetic changes enable cell survival under high ROS levels by activating antioxidant transcription factors or increasing NADPH via the pentose phosphate pathway (PPP). During progression and metastasis, tumor cells adapt to oxidative stress by increasing NADPH in various ways, including activation of AMPK, the PPP, and reductive glutamine and folate metabolism.

• Authors: John D Hayes, Albena T Dinkova-Kostova, Kenneth D Tew
• Journal: Cancer cell (Cancer Cell) Vol. 38 Issue 2 Pg. 167-197 (08 10 2020) ISSN: 1878-3686 [Electronic] United States
• PMID: 32649885 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Antioxidants
• Reactive Oxygen Species
• NADP
• Glucose

Topics

• Animals
• Antioxidants (metabolism)
• Apoptosis (genetics)
• Energy Metabolism (genetics)
• Glucose (metabolism)
• Humans
• NADP (metabolism)
• Neoplasms (genetics, metabolism)
• Oxidative Stress
• Reactive Oxygen Species (metabolism)